A hollow, pumplike organ of blood circulation, composed mainly of rhythmically contractile smooth muscle, located in the chest between the lungs and slightly to the left and consisting of four chambers: a right atrium that receives blood returning from the body via the superior and inferior vena cavae, a right ventricle that pumps the blood through the pulmonary artery to the lungs for oxygenation, a left atrium that receives the oxygenated blood via the pulmonary veins and passes it through the mitral valve, and a left ventricle that pumps the oxygenated blood, via the aorta, throughout the body.