- Industry: Medical
- Number of terms: 700
- Number of blossaries: 0
- Company Profile:
Engagement in a programme leading to differentiation. For a stem cell, this means it no longer retains the ability to self-renew.
Industry:Medical
Investigation of properties of single cells. Essential for formal demonstration of self-renewal and potency.
Industry:Medical
A research study in human subjects to answer specific questions about vaccines or new therapies or new ways of using known treatments. Clinical trials are used to determine whether new drugs or treatments are both safe and effective. Trials take place in four phases: Phase I tests a new drug or treatment in a small group; Phase II expands the study to a larger group of people; Phase III expands the study to an even larger group of people; and Phase IV takes place after the drug or treatment has been licensed and marketed.
Industry:Medical
The process of turning scientific knowledge into approved medical treatments, through a series of carefully controlled research and approval steps.
Industry:Medical
Reconstitution of tissue by functional incorporation of transplanted stem-cell progeny. Distinct from 'bystander' trophic, anti-inflammatory or immunomodulatory effects of introduced cells.
Industry:Medical
A population of cells all carrying the same genes, grown in the laboratory through many cycles of growth and division over many generations of cells.
Industry:Medical
Cell that can produce a new cancer upon transplantation. A key property of a cancer stem cell.
Industry:Medical
The growth of cells in a laboratory dish for experimental research. The cells are grown in a solution, or medium, that contains nutrients and growth factors. Different factors can be added to the culture medium to initiate changes in cell behaviour.
Industry:Medical
Self-renewing cell responsible for sustaining a cancer and for producing differentiated progeny that form the bulk of the cancer. Cancer stem cells identified in leukaemias and certain solid tumours are critical therapeutic targets.
Industry:Medical
Cell division resulting in two daughter cells with different properties. Observed in some but not all stem cells and can occur in other types of progenitor cell.
Industry:Medical
